The 60 Second Metabolist


Flaminia FanelliUniversity of Bologna, Italy

Referring article:
Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women


Giles YeoUniversity of Cambridge, UK

Referring article:
Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing


Randy J. Seeley, Henriette Frikke-SchmidtUniversity of Michigan Health System, Ann Arbor, USA

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Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice


Donald ScottIcahn School of Medicine at Mount Sinai, New York, USA

Referring article:
DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet


Jennifer LeeUniversity of Toronto, Canada

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Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport


András Frankó University Hospital Tübingen, Germany

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Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice


Emily L. GoldbergYale School of Medicine,

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Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation


Carly Cederquist, Valentina PerissiBoston University School of Medicine, Boston, USA

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Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue


Charlotte Schmitt, Alexandra GrosfeldSorbonne Universités, Paris, France

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Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected role in gut homeostasis


Tamires Zanotto, Mario SaadState University of Campinas, Campinas, Brazil

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Blocking iNOS and endoplasmic reticulum stress synergistically improves insulin resistance in mice


Lars Stechemesser, Elmar AignerParacelsus Medical University, Salzburg, Austria

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Metabolomic profiling identifies potential pathways involved in the interaction of iron homeostasis with glucose metabolism


Cheryl CeroUniversity of Minnesota, Minneapolis, USA

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The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis


Mitchell Lazar, Jarrett RemsbergPerelman School of Medicine at the University of Pennsylvania, Philadelphia, USA

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Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion


Rana Gupta, Mengle Shao, Chelsea HeplerThe University of Texas Southwestern Medical Center at Dallas, TX, USA

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Fetal development of subcutaneous white adipose tissue is dependent on Zfp423


Qingzhang ZhuThe Scripps Research Institute, Jupiter, USA

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Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain


Yossi TamThe Hebrew University of Jerusalem, Israel

Referring article:
Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader–Willi syndrome


Kevin Williams, Jia Sun, Ting Yao, Yong GaoThe University of Texas Southwestern Medical Center at Dallas, TX, USA

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Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons


Christian Benedict, Jonathan CedernaesUppsala University, Sweden

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Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals


Mark A. Febbraio, Robert S. Lee-YoungBaker IDI Heart & Diabetes Institute, Melbourne, Australia

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Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle


Ammy M. Santiago, Vanessa H. RouthRutgers University, Newark, USA

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Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons


Anna M. D’souzaUniversity of British Columbia, Vancouver, Canada

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Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lepob/ob mice


Gregory MortonUniversity of Washington, Seattle, USA

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Physiological role for leptin in the control of thermal conductance


Sarbani GhoshalThe Scripps Research Institute, Jupiter, USA

Referring article:
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway


Paula MeraColumbia University, New York, USA

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Osteocalcin is necessary and sufficient to maintain muscle mass in older mice


Kavaljit H. Chhabra, Malcolm J. Low University of Michigan, Ann Arbor, USA

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Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity


Kevin VivotUniversité de Montréal, Montréal, Canada

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The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets


Maria NamwanjeColumbia University, New York, USA

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Genetic backgrounds determine brown remodeling of white fat in rodents


Maude GiroudUniversity of Nice Sophia Antipolis, France

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miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function


Heather C. DenrocheUniversity of British Columbia, Vancouver, Canada

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The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy


Ursula H. NeumannUniversity of British Columbia, Vancouver, Canada

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Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival


Maria MavrikakiThe Scripps Research Institute and Saint Louis University School of Medicine, USA

Referring article:
Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss


Joel K. Elmquist, Kevin W. Williams and Jong-Woo SohnUniversity of Texas Southwestern Medical Center, Dallas, USA

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Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons


Dirk van Moorsel and Jan HansenMaastricht University Medical Center, The Netherlands

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Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity


Shin J. LeeETH Zürich, Switzerland

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Limiting glucocorticoid secretion increases the anorexigenic property of Exendin-4


Jelena Kolic and Patrick E. MacDonaldUniversity of Alberta, Canada

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PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets


Mark O. HuisingUniversity of California, USA

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Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets


Abigail L. ShearinUniversity of Pennsylvania, USA

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Lack of AKT in adipocytes causes severe lipodystrophy


Philipp E. Scherer and Risheng YeThe University of Texas Southwestern Medical Center, USA

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Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges


Jonathan F. GillUniversity of Basel, Switzerland

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PGC-1α expression in murine AgRP7 neurons regulates food intake and energy balance


David A. Guertin and Peter L. LeeUniversity of Massachusetts Medical School, USA

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Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease


Trevor J. BidenGarvan Institute of Medical Research, Sydney, Australia

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A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens


James D. Johnson and Tobias BootheUniversity of British Columbia, Vancouver, Canada

Referring article:
Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells


A. G. ZieglerInstitute of Diabetes Research, Helmholtz Zentrum München, Germany

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Primary prevention of beta-cell autoimmunity and type 1 diabetes - The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives


Lori M. ZeltserColumbia University, USA

Referring article:
Postnatal undernutrition delays a key step in the maturation of hypothalamic feeding circuits


Lora K. HeislerRowett Institute of Nutrition and Health, University of Aberdeen, UK

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Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons


Anna KamitakaharaUniversity of Southern California, USA

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Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia


Mario Ost and Verena ColemanGerman Institute of Human Nutrition, Nuthetal

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Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action


Stephan HerzigInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Germany

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Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia


Susanne Raab and Sabine SewingRoche Innovation Center Basel, Switzerland

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Incretin-like effects of small molecule trace amine-associated receptor 1 agonists


Sonia Fernández-Veledo, Miriam Ejarque, Victòria Ceperuelo-Mallafré and Joan VendrellUniversitat Rovira i Virgili, Tarragona, Spain

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Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans


Maria Razzoli and Alessandro BartolomucciUniversity of Minnesota, Minneapolis

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Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis


Katarina MarcinkoMcMaster University, Hamilton, Canada

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High intensity interval training improves liver and adipose tissue insulin sensitivity


Philipp E. Scherer, Risheng Ye and Qiong A. WangThe University of Texas Southwestern Medical Center, Dallas

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Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase


Nigel BeatonETH Zurich

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TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling


Alyssa HastyVanderbilt University School of Medicine

Referring article:
Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment


Philipp E. Scherer and Christine M. KusminskiThe University of Texas Southwestern Medical Center

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E4orf1 induction in adipose tissue promotes insulin-independent signaling in the adipocyte


Samantha E. Adamson and Norbert LeitingerUniversity of Virginia

Referring article:
Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes


Helen Soedling and Guy A. RutterImperial College London

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Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressin


Dionysios V. ChartoumpekisUniversity of Pittsburgh

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Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice


Jennifer Rojas and Miles MatsenUniversity of Washington

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Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response


Stefan Bröer and Yang JiangThe Australian National University, Canberra

Referring article:
Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control


Andrew A. ButlerSaint Louis University School of Medicine

Referring article:
Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance


Giles S.H. YeoUniversity of Cambridge

Referring article:
FTO is necessary for the induction of leptin resistance by high-fat feeding


Rebecca HaeuslerColumbia University, New York

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Decreased expression of hepatic glucokinase in type 2 diabetes


Judith Y. Altarejos and Geun Hyang KimSanford-Burnham Medical Research Institute, Orlando

Referring article:
Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes


Christopher NogiecBoston University

Referring article:
Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes


Daniel J. DruckerUniversity of Toronto

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Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction


Lori M. ZeltserColumbia University, New York

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Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness


Ashley N. Kamimae-LanningOregon Health & Science University, Portland

Referring article:
Maternal high-fat diet and obesity compromise fetal hematopoiesis


Thierry AlquierMontreal Diabetes Research Center and Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM)

Referring article:
Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice


Ting ZhangUniversity of Pittsburgh School of Medicine

Referring article:
Glucose-regulated insulin production in the liver improves glycemic control in type 1 diabetic mice


Gerard KarsentyColumbia University, New York

Referring article:
The class II histone deacetylase HDAC4 regulates cognitive, metabolic and endocrine functions through its expression in osteoblasts


Eleftheria Maratos-Flier and Mark HermanBeth Israel Deaconess Medical Center, Boston

Referring article:
Fructose ingestion acutely stimulates circulating FGF21 levels in humans


Jennifer TaherUniversity of Toronto and The Hospital for Sick Children, Toronto

Referring article:
GLP-1 receptor agonism ameliorates hepatic VLDL overproduction and de novo lipogenesis in insulin resistance


Erik RichterMolecular Physiology Group, University of Copenhagen

Referring article:
Acute mTOR Inhibition Induces Insulin Resistance and Alters Substrate Utilization in vivo


Guillaume de Lartigue and Charlotte C. RonveauxUC Davis School of Veterinary Medicine

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Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity


Heike Münzberg and Kavon Rezai-ZadehPennington Biomedical Research Center, Louisiana State University System

Referring article:
Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake


Daniela CotaNeurocentre Magendie, Bordeaux

Referring article:
CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin


Carey Nien-Kai Lumeng and Kanakadurga SingerUniversity of Michigan Medical School

Referring article:
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells


Peter A. Crawford and Rebecca C. SchugarCenter for Cardiovascular Research, Washington University

Referring article:
Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling


Alexandre BenaniCentre des Sciences du Gout et de l'Alimentation, Université de Bourgog

Referring article:
The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice


Kai Sun and Philipp E. SchererUniversity of Texas Southwest Medical Center

Referring article:
Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure


Monica ImbernonUniversity of Santiago de Compostela, Instituto de Investigación Sanitaria

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Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP


Sean L. McGeeDeakin University

Referring article:
Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action


Franck Mauvais-JarvisTulane University Health Sciences Center, New Orleans

Referring article:
Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice


Martin HeniUniversity of Tübingen

Referring article:
Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex


Mona A. AbrahamUniversity of Toronto

Referring article:
Hypothalamic glucagon signals through the KATP channels to regulate glucose production


Kyle L. Hoehn & Evan B. TaddeoUniversity of Virginia

Referring article:
Opening of the mitochondrial permeability transition pore is required for insulin resistance in skeletal muscle


Kyle L. Hoehn & Brandon M. KenwoodUniversity of Virginia

Referring article:
Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane


Stefano SchiaffinoVenetian Institute of Molecular Medicine

Referring article:
Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock


Giovanni MarsicanoUniversity of Bordeaux

Referring article:
Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes


Gina LeinningerMichigan State University

Referring article:
Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity


Uberto Pagotto & Carmelo QuartaUniversity of Bologna

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11C-meta-hydroxyephedrine PET/CT imaging allows in vivo study of adaptive thermogenesis and white-to-brown fat conversion


Richard Di MarchiIndiana University

Referring article:
Peptide lipidation stabilizes structure to enhance biological function


Christa PattersonUniversity of Michigan

Referring article:
Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction


Dana SmallThe John B. Pierce Laboratory

Referring article:
Neuroimaging the interaction of mind and metabolism in humans


Sabrina DianoYale University

Referring article:
Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice


Kevin GroveOregon Health & Science University

Referring article:
High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate


Giles YeoUniversity of Cambridge

Referring article:
Uncovering the biology of FTO

The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Flaminia Fanelli
University of Bologna, Italy
Referring article

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