Cover Story

The illustration shows the colocalization of STAT5 (red) in leptin receptor (LepR-b)-expressing neurons in the arcuate nucleus of the mouse brain. Patterson et al. examined the role for signaling via leptin receptor Tyr1077 (which is responsible for STAT5 activation) in the control of physiology by leptin. Replacement of the leptin receptor in mice by a mutant version in which Tyr1077 is replaced by Phe results in only modest changes in energy balance and metabolism, but interferes with reproductive function, suggesting an important role for this signaling pathway in the control of the neuroendocrine reproductive axis, but not energy balance.

Full Text
The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Jennifer Lee
University of Toronto, Canada
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.molmetab.com/user/alerts
Conferences & Events
May
2 − 4
2017
Translational and Therapeutic Perspectives of Brown Adipose
Copenhagen, Denmark
May
7 − 10
2017
BCW-ISG 2017
Beta Cell Workshop

Dresden, Germany
May
9 − 13
2017
Gastrointestinal Control of Metabolism
Copenhagen, Denmark
May
9 − 13
2017
Neuronal Control of Appetite, Metabolism and Weight
Copenhagen, Denmark
Supported by