This image shows alpha (green) and beta (red) cells in fetal pancreatic islets of Japanese macaques. Comstock et al. investigated the effects of maternal diet and postnatal diet on offspring in non-human primates. Regardless of maternal diet (high fat or control), offspring fed a postnatal, high fat diet (HFD) had increases in islet mass compared to offspring fed a postnatal control diet. However, the underlying cause of the increase was different between groups. Only the combination of maternal HFD and postnatal HFD (HFD/HFD) resulted in increased islet size and a decreased number of alpha cells, suggesting that HFD during pregnancy may cause long-term changes in islet cell morphology, particularly in alpha cells.
The large view of the image represents islets from an HFD/HFD offspring. For comparison, the smaller view within the frame shows islets from a control (CTR/CTR).Full Text