Fibroblast growth factor 21 (FGF21) is a recently discovered hormone primarily produced by the liver and adipose tissue which has pleiotropic actions on
glucose and lipid homeostasis. In humans, circulating levels of FGF21 are elevated in association with obesity, insulin resistance, hypertriglyceridemia,
nonalcoholic fatty liver disease and type 2 diabetes. To date, no stimulus has been identified that can acutely increase serum FGF21 in either humans or
animals on the time-scale of minutes to a few hours.
This study demonstrates for the first time that circulating FGF21 levels respond acutely to a dietary challenge - the ingestion of a fructose load.
Moreover, the authors show that baseline levels of FGF21 are elevated in subjects with features of metabolic disease and that, in this state, the FGF21
response to fructose ingestion is further enhanced.Full Text