Featured Articles

Volume 1 | No. 1-2 | December 2012

Link between leptin action and female reproductionLeptin binding to its receptor (LepR-b) promotes the tyrosine phosphorylation of three sites on LepR-b. Patterson and colleagues demonstrate that female mice mutant for LepR-b Tyr1077 display impairments in estrous cycling.

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Regulation of β-cell turnover by TOSOIn both T1DM and T2DM, the major mechanism leading to decreased β-cell mass is increased β-cell apoptosis. Dharmadhikari and colleagues show that switching off the Fas pathway by TOSO blocks β-cell apoptosis and increases proliferation in human islets.

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Ghrelin as mediator of circadian and visual cues for the hypothalamic arousal systemHorvath and colleagues demonstrate that ghrelin-immunolabeled neurons receive synaptic input from circadian and secondary visual projections and innervate orexin neurons. Hypothalamic ghrelin expression shows circadian oscillation and inhibits the activity of arousal promoting orexin neurons.

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Extra-hypothalamic site for leptin-mediated regulation of feedingThe anorectic effects of leptin are generally attributed to melanocortin signaling in the arcuate nucleus of the hypothalamus. Billes and colleagues show that leptin reduces food intake also via dopaminergic signaling involving the dopamine D2 receptor.

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Hypothalamic angiopathy – a novel facet of metabolic syndrome pathophysiologyThere is increasing evidence that hypothalamic processes beyond neuronal signaling may be involved in the pathogenesis of the metabolic syndrome. Yi and colleagues report the occurrence of hypothalamic angiopathy, including neo- and hypervascularization, following chronic exposure to a high-calorie environment

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Giles Yeo
University of Cambridge, UK
Referring article

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