Featured Articles

Volume 2 | No. 1 | February 2013

Maternal programming: High fat diet during pregnancy affects α cell plasticity in offspringComstock and colleagues demonstrate that fetal offspring of high fat diet (HFD) fed macaques display a significant reduction in α cell mass and decreased expression of transcription factors involved in α cell differentiation. In offspring maintained on HFD during the early post-natal period abnormalities in α cell plasticity persists.

Abstract | PDF



Ghrelin regulates hypothalamic prolyl carboxypeptidase expressionHypothalamic prolyl carboxypeptidase (PRCP) is involved in the regulation of energy metabolism by catalyzing the inactivation of α-MSH. Jeong and colleagues show that ghrelin induces Prcp mRNA up-regulation during fasting, which may be an additional mechanism to decrease melanocortin signaling.

Abstract | PDF



The majority of FGF21’s metabolic actions are mediated by FGFR1 in adipose tissueEndocrine FGF21 is a multifunctional metabolic regulator, which can bind to FGF receptors in the presence of a specific co-factor. Adams and colleagues reveal that binding of FGF21 to FGFR1 in adipose tissue is responsible for the majority of known FGF21 driven metabolic effects, which also involve cross-tissue communication.

Abstract | PDF



Seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1Mutations in the seipin encoding gene BSCL2 cause the most severe human lipodystrophy. Sim and colleagues describe the first direct molecular interaction identified for seipin: Seipin serves as an ER membrane adaptor for the phosphatidic acid phosphatase lipin 1, which is essential for adipocyte differentiation and lipid biogenesis.

Abstract | PDF



Glucose sensing in the portal veinDelaere and colleagues demonstrate that under the conditions of small glucose flux, such as that contributed by intestinal gluconeogenesis elicited by protein-enriched diets, portal glucose detection occurs independently of GLUT2. The authors suggest that under these conditions SGLT3 is the relevant glucose sensor.

Abstract | PDF



The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Jennifer Lee
University of Toronto, Canada
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.molmetab.com/user/alerts
Conferences & Events
May
2 − 4
2017
Translational and Therapeutic Perspectives of Brown Adipose
Copenhagen, Denmark
May
7 − 10
2017
BCW-ISG 2017
Beta Cell Workshop

Dresden, Germany
May
9 − 13
2017
Gastrointestinal Control of Metabolism
Copenhagen, Denmark
May
9 − 13
2017
Neuronal Control of Appetite, Metabolism and Weight
Copenhagen, Denmark
Supported by