Featured Articles

Volume 3 | No. 6 | Sept. 2014

Connection lost - Deletion of vagal leptin signaling leads to obesityWith their previous data showing that leptin resistance is an early event in high-fat diet induced hyperphagia and weight gain, the current data of de Lartigue and colleagues strongly suggest that defects in leptin signaling in the vagal afferent pathway is a novel mechanism for the initiation of obesity.

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SOCS3 orchestrates diet-induced changes on glucose homeostasisThe objective of the study of Pedroso and colleagues was to investigate the effects of genetic ablation of the Socs3 gene in different mouse models to elucidate the role played by SOCS3 in the regulation of leptin sensitivity, diet-induced obesity and glucose homeostasis. Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity.

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The histone acetyltransferase MOF controls energy balanceThe results of Brenachot and colleagues suggest that Mof silencing in the mediobasal hypothalamus of mice fed a high fat diet reduces hypothalamic polysialic acid levels, causes overfeeding and exacerbates diet-induced obesity, indicating a role for MOF in the brain control of energy balance.

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Acute mTOR inhibition induces insulin resistanceIn this study, Kleinert and colleagues provide evidence that acute mTOR inhibition leads to insulin resistance and glucose intolerance along with changes in substrate utilization. Insulin-mediated glucose transport into muscle cells is perturbed despite normal GLUT4 translocation, which points to an intracellular glucose handling defect.

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Protective effect of E2/ERα regarding adipose tissue functionThe data of Kim and colleagues suggest that adipose tissues are protected from HIF-1 induced fibrosis and inflammation by an E2/ERα dependent, Phd3 mediated mechanism, providing a mechanistic explanation for the protective effect of E2/ERα regarding adipose tissue function.

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PLIN5 deletion causes insulin resistance in muscleThe data of Mason and colleagues support the hypothesis that PLIN5 is required to match lipolysis of intramyocellular triacylglycerol to metabolic demands, which helps to maintain insulin sensitivity in skeletal muscle.

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Dietary priming of hematopoietic progenitors contributes to adipose tissue inflammationSinger and colleagues examined the hypothesis that myeloid cell production by hematopoietic stem cells HSCs is potentiated by high fat diet induced obesity and plays a crucial role in the generation of pro-inflammatory tissue macrophages. This study suggests that obesity may have life-long effects on inflammatory responses by altering HSC function.

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Interaction of PPARG and FFAR1In this work, Wagner and colleagues provide evidence for a biologically relevant crosstalk between PPARG and FFAR1 signaling in the regulation of insulin secretion in humans.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Randy J. Seeley, Henriette Frikke-Schmidt
University of Michigan Health System, Ann Arbor, USA
Referring article

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