Featured Articles

Volume 3 | No. 7 | October 2014

Leptin receptor neurons neurons regulate body weight independent of food intakeThe data of Rezai-Zadeh and colleagues indicate that leptin receptors in the dorsomedial hypothalamus induce energy expenditure via brown adipose tissue thermogenesis and locomotor activity with similar magnitudes and chronology, suggesting that both thermogenic mechanisms are initiated by the activation DMH/DHA LepRb neurons.

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AgRP neurons control meal patternThe results of Tan and colleagues confirm a key role for AgRP/NPY neurons in the response to restricted feeding suggesting that it is a key neural component of the food entrainable oscillator.

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CB1 receptors regulate adiposity and glucose metabolismThe data of Cardinal and colleagues demonstrate that CB1 receptors in the hypothalamic ventromedial nucleus (VMN) determine metabolic and molecular adaptations to different environmental dietary conditions. In order to do so, CB1 receptors in VMN neurons orchestrate peripheral use of substrates and fine-tune sensitivity (or resistance) to the actions of leptin.

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Regulation of ghrelin secretion in the contexts of obesity and weight lossIn the present study, Uchida and colleagues tested the hypothesis that circulating ghrelin levels are altered in obesity and after weight loss by Roux-en-Y gastric bypass through changes in ghrelin cell responsiveness to physiological cues.

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Fractalkine protects beta-cells against TNFαIn this study, Rutti and colleagues provide evidence that fractalkine (CX3CL1) is a protective factor against the adverse effects of TNFα on beta-cells. CX3CL1 impacts human islets by decreasing glucagon secretion but not insulin and it decreases basal apoptosis of human beta-cells.

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Ca2+ release is not necessary to increase glucose transportIn this study, Jensen and colleagues provide evidence that combined AMPK activation and mechanical stress can fully account for the contraction-stimulated glucose transport-response ex vivo, strongly suggesting that AMPK and stretch-activated signalling, but not sarcoplasmatic reticulum Ca2+ per se, regulates glucose transport during skeletal muscle contraction.

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Myocardial ketone oxidation is cardioprotectiveThe data of Schugar and colleagues demonstrate that myocardial ketone oxidation is cardioprotective in sepsis and pressure overload, it regulates myocardial protein acetylation and attenuates stress-induced ROS accumulation.

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Foxo1 regulates the activity of the sympathetic nervousThe results of Kajimura and colleagues demonstrate that the transcription factor FoxO1 is expressed in neurons of the locus coeruleus and that it favors Dbh expression and catecholamine synthesis. As a result, FoxO1 regulates physiological processes such as energy expenditure, glucose metabolism, and bone mass accrual that are under the influence of the sympathetic nervous system.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Flaminia Fanelli
University of Bologna, Italy
Referring article

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