Featured Articles

Volume 4 | No. 2 | February 2015

Central insulin signaling modulates hypothalamus–pituitary–adrenal axis responsivenessChong and colleagues show evidence that insulin receptor (InsR) signaling in hypothalamic neurons provides an important source of crosstalk between energy status and stress reactivity. InsR signaling in AgRP/NPY neurons appears to promote arginine vasopressin release, while signaling in other hypothalamic neurons likely acts in an opposite fashion.

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Blockade of VEGF-C and VEGF-D under high-fat dietKaraman and colleagues reveal an unanticipated role of the lymphangiogenetic factors VEGF-C and -D in the mediation of metabolic syndrome-associated adipose tissue inflammation. Blockage of the two VEGFR-3 ligands improves systemic insulin sensitivity and protects the liver against high-fat diet induced steatosis, associated with reduced adipose tissue inflammation.

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A gut–brain neural circuitSoty and colleagues report that deficient intestinal gluconeogenesis (IGN) per se is sufficient to initiate metabolic impairment characteristic of a pre-diabetic state in mice. Deregulation in a key target of (IGN), the homeostatic hypothalamic function, is a mechanistic link.

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SIRT1 enhances glucose toleranceMice with moderate overexpression of SIRT1 exhibit better glucose tolerance and insulin sensitivity even on a low fat diet. Boutant and colleagues illustrate how SIRT1 gain-of-function can improve insulin sensitivity by acting as a gauge for the brown adipose tissue response to β3-adrenergic stimuli.

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Cardiomyocyte glucagon receptor signalingThere is increasing interest in the development of drugs that reduce or activate glucagon receptor (Gcgr) signaling for the treatment of metabolic disorders such as diabetes and obesity. However, the cardiovascular consequences of manipulating glucagon action are poorly understood. Ali and colleagues demonstrate that exogenous glucagon administration has negative actions on the ischemic heart, whereas reduction in cardiac glucagon action in GcgrCM-/- mice results in marked cardioprotection.

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Angiopoietin-like 4 in brainVienberg and colleagues explore the regulation and role of angiopoietin-like 4 (Angptl4) in the brain in mouse models of diabetes and through the use of the Angptl4 knockout mice. Angptl4 expression in hypothalamus is upregulated in both type 1 and type 2 diabetic animal models. However, in contrast to the periphery, central Angptl4 does not regulate lipoprotein lipase activity, but appears to participate in the metabolic crosstalk between glia and neurons.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Jennifer Lee
University of Toronto, Canada
Referring article

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