Featured Articles

Volume 4 | No. 5 | May 2015

Adipocyte SIRT1 knockout improves metabolic functions in obesityMayoral and colleagues establish that SIRT1 downregulation in adipose tissue plays a previously unknown role in long-term inflammation resolution mediated by PPARγ activation. During chronic high-fat diet Sirt1 adipocyte-specific knockout mice became more insulin sensitive, glucose tolerant, and less inflamed than wildtype controls. The data presented may provide novel approaches to the treatment of type 2 diabetes.

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Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expressionLu and colleagues advance our understanding of leptin gene expression and show that NF-Y controls the expression of leptin and other adipocyte genes. Animals with a knockout of NF-YA develop a moderately severe lipodystrophy with low leptin levels and a metabolic phenotype that is remediable with leptin therapy.

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Reduced neutral amino acid availability improves glycaemic controlJiang and colleagues identify the neutral amino acid transporter B0AT1 as a potential target to treat type 2 diabetes. Mice lacking intestinal and renal B0AT1 present with an overload of amino acids in the lumen of the intestine and reduced systemic amino acid availability. The resulting phenotype mediated by GLP-1 and FGF21 is characterised by improved glycaemic control.

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Munc18c mediates exocytosis of pre-docked and newcomer insulin granulesZhu and colleagues illuminate in human beta-cells that Munc18c acts on distinct pools of secretory granules (SGs) to mediate biphasic glucose-stimulated insulin secretion (GSIS). Depletion of endogenous Munc18c with consequent reduction of Syn-4 levels in islet beta-cells reduces exocytosis of predocked and newcomer SGs in first-phase GSIS and newcomer SGs in second-phase GSIS.

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Roux-en-Y gastric bypass is associated with gonadal adipose tissues browningNeinast and colleagues suggest a possible mechanism by which Roux-en-Y gastric bypass (RYGB) improves obesity-related metabolic sequelae. Their results indicate that RYGB may affect beige adipocyte enrichment of adipose tissues by altering sympathetic and natriuretic peptide-related circuits.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Jennifer Lee
University of Toronto, Canada
Referring article

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