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The illustration shows the colocalization of STAT5 (red) in leptin receptor (LepR-b)-expressing neurons in the arcuate nucleus of the mouse brain. Patterson et al. examined the role for signaling via leptin receptor Tyr1077 (which is responsible for STAT5 activation) in the control of physiology by leptin. Replacement of the leptin receptor in mice by a mutant version in which Tyr1077 is replaced by Phe results in only modest changes in energy balance and metabolism, but interferes with reproductive function, suggesting an important role for this signaling pathway in the control of the neuroendocrine reproductive axis, but not energy balance.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Isa Kolbe, Henrik Oster
University of L├╝beck, Germany
Referring article

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