Cover Story

Treatment of type 2 diabetes mellitus (T2DM) with glucagon-like peptide-1 receptor agonists (GLP-1RAs) leads to better glycemic control, reduced body weight, and improvement in several cardiovascular risk factors, which has been demonstrated to be accompanied by improved micro- and macrovascular outcomes. However, many patients treated with GLP-1RAs do not reach their glycemic targets, and weight loss achieved with these agents remains well below what can be attained with bariatric surgery. Therefore, there are still opportunities to improve the existing GLP-1RA class.

Coskun et al. describe a novel, single-peptide, dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, LY3298176. The dual functionality of the peptide is described in preclinical in vitro and in vivo models, and clinical assessment demonstrated that administration of LY3298176 led to decreased glucose levels and decreased body weight in healthy individuals during a multiple ascending dose study, and in a randomized, 4-week, Phase 1b trial in T2DM patients.

Full Text
The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Mary-Ellen Harper, Rajaa Sebaa, Michael Downey
University of Ottawa, Ottawa, ON, Canada
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.sciencedirect.com/journal/molecular-metabolism
Conferences & Events
August
25 − 30
2019
Epigenomics, Nuclear Receptors and Disease
Spetses Island, Greece
September
9 − 12
2019
Ageing and Regeneration
Innsbruck, Austria
September
23 − 25
2019
7th Helmholtz Diabetes Conference
Munich, Germany
October
15 − 18
2019
Nature Conference: Advances in Metabolic Communication
Rio de Janeiro, Brasil
October
15 − 18
2019
13th European Nutrition Conference
Dublin, Ireland
October
27 − 31
2019
Metabolism in Action
Hillerod, Denmark
December
6 − 8
2019
Cachexia, Sarcopenia and Muscle Wasting
Berlin, Germany
Media Coverage
Supported by