Cover Story

Hyperthyroidism is associated with increased metabolism and an increased body temperature. The molecular nature of the increased metabolism has not been clarified although several investigations point to the possibility that the increased metabolism is due to activation of brown adipose tissue through a centrally mediated effect. In the brown fat cells, thermogenesis would occur due to activation of the brown-fat-specific uncoupling protein 1 (UCP1).

To test this hypothesis, Dittner et al. examined thyroid thermogenesis induced by peripherally administered thyroxine in wild-type mice as compared to mice devoid of UCP1 (UCP1 KO mice). The investigations were performed at thermoneutrality to avoid activation of brown adipose tissue by cold stress and to better approach human conditions. The authors found that thyroid thermogenesis was practically independent of the presence of UCP1. Also, the increase in body temperature was UCP1-independent; this elevated body temperature was not hyperthermia but was due to a thyroid hormone-induced increase in the defended body temperature: pyrexia.

Full Text
The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Daniela Cota
INSERM, Bordeaux, France
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.sciencedirect.com/journal/molecular-metabolism
Conferences & Events
October
15 − 18
2019
Nature Conference: Advances in Metabolic Communication
Rio de Janeiro, Brasil
October
15 − 18
2019
13th European Nutrition Conference
Dublin, Ireland
October
27 − 31
2019
Metabolism in Action
Hillerod, Denmark
December
6 − 8
2019
Cachexia, Sarcopenia and Muscle Wasting
Berlin, Germany
Media Coverage
Supported by