Cover Story

Because of their pleiotropic effects on energy and glucose homeostasis, G protein coupled receptors (GPCRs) expressed in white adipose tissue (WAT) and brown adipose tissue (BAT) are considered potential targets for the treatment of metabolic diseases. There are four main families of G proteins: Gi/Go, Gq, Gs, and G12. In rodents, most of the positive effects of the sympathetic nervous system on adipose tissue are attributed to norepinephrine activation of Gs-coupled beta 3 adrenergic receptors located at the surface of the adipocytes.

The groups of Caron et al. as well as Wang et al. did similar experiments to further elucidate the role of Gs signaling in adipocytes: they used Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), chemogenetically-engineered proteins that allow spatial and temporal control of G protein signaling in vivo because they can only be activated by an exogenously administered drug. Both groups report that Gs signaling in adipocytes is a potent regulator of systemic glucose homeostasis, improving glucose tolerance and insulin sensitivity.

Full Text
The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Ildiko Kasza, Caroline Alexander
University of Wisconsin-Madison, United States
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.sciencedirect.com/journal/molecular-metabolism
Conferences & Events
September
23 − 25
2019
7th Helmholtz Diabetes Conference
Munich, Germany
October
15 − 18
2019
Nature Conference: Advances in Metabolic Communication
Rio de Janeiro, Brasil
October
15 − 18
2019
13th European Nutrition Conference
Dublin, Ireland
October
27 − 31
2019
Metabolism in Action
Hillerod, Denmark
December
6 − 8
2019
Cachexia, Sarcopenia and Muscle Wasting
Berlin, Germany
Media Coverage
Supported by