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This image depicts an immunofluorescence photo of different muscles showing the distinct muscle fiber types: normal fiber type profile in transverse section of fast extensor digitorum longus (top) and slow soleus (bottom) from a muscle-specific Bmal1 KO mouse stained with anti-myosin antibodies specific for type-1/slow (blue), type-2A (green) and type 2B (red) myosin heavy chains. Type 2X fibers are unstained and appear black (10x photo courtesy of Dr. Stefano Ciciliot). In this study, Dyar et al. generated two skeletal muscle-specific Bmal1 knockout models to investigate the physiological role of the intrinsic muscle clock in glucose metabolism. The main result of this study is the finding that muscle-specific Bmal1 ablation causes muscle insulin resistance and altered muscle glucose metabolism.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Andrea Rozo, Doris Stoffers
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
Referring article

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