Cover Story

Insulin is reciprocally regulated with the stress hormone corticosterone, consistent with the idea that it provides inhibitory tone to the hypothalamus-adrenal-pituitary axis. Disruptions of insulin receptor (InsR) signals in Nkx2.1-expressing regions of the hypothalamus result in elevated arginine vasopressin (AVP) levels at baseline and heightened neuroendocrine responses to restraint stress. In contrast, disrupting InsR signals in neurons of the arcuate nucleus of the hypothalamus expressing Agrp leads to reduced AVP release in the median eminence.

This issue's cover illustrates the complicated crosstalk between energy status and stress reactivity mediated by the insulin receptor.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.

Ursula Neumann
University of British Columbia, Vancouver, Canada
Referring article

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