Cover Story

Extracellular ATP-derived nucleotides and nucleosides are important autocrine regulators of adipocyte function. However, the mechanisms of ATP release from adipocytes are not known.

Samantha E. Adamson et al. now identified Panx1 channels as mediators of controlled extracellular nucleotide release from adipocytes. Further, they demonstrated that Panx1-dependent ATP release is required for full activation of insulin-induced glucose uptake in adipocytes and identified insulin as a novel mediator of Panx1 channel activation.

The cover illustration summarizes the proposed signaling pathway in which insulin stimulates glucose uptake by activation of Panx1: Insulin mediates opening of Panx1 channels and triggers ATP release from adipocytes. ATP signals through the purinergic P2 receptor family or is converted to adenosine (ADO) by the action of ectonucleotidases. After receptor binding, ADO stimulates glucose uptake by promoting the incorporation of Glut4 into the plasma membrane.



Full Text
The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Andrea Rozo, Doris Stoffers
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.molmetab.com/user/alerts
Conferences & Events
September
17 − 19
2017
5th Helmholtz-Nature Medicine Diabetes Conference
Munich, Germany
October
1 − 5
2017
Lifetime Influence of Genes and Environment
Copenhagen, Denmark
October
15 − 17
2017
Cell Symposia: Metabolic Disease Therapies
San Diego, USA
Supported by