Cover Story

Osteocalcin is a bone-derived hormone that regulates a growing number of physiological functions. In particular, although Osteocalcin is not expressed in any part of the brain before or after birth, Osteocalcin-/- mice have increased anxiety-like behavior and depression, decreased exploratory behavior, and impaired learning and memory when compared to wildtype littermates. In the brain, osteocalcin promotes the synthesis of monoamine neurotransmitters and inhibits synthesis of GABA by regulating the expression of key enzymes. Given that osteocalcin is produced only by osteoblasts, Khrimian et al. asked whether an impairment in osteoblast differentiation and function, as may occur in various skeletal dysplasias or with aging, could affect cognition or anxiety. They studied Runx2+/- mice, which phenocopy the haploinsufficiency that is observed in patients with cleidocranial dysplasia (CCD), a classical skeletal dysplasia in which cognitive functions are also affected. Their results suggest that a decrease in osteocalcin is indeed the cause for these cognitive impairments. Moreover, it is implied that bone anabolic treatments for degenerative diseases of the skeleton, such as osteoporosis, may also have a beneficial effect on cognitive function and anxiety-like behavior, whereas anti-resorptive agents may potentially be detrimental.

Full Text
The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Florian Merkle
University of Cambridge, UK
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.sciencedirect.com/journal/molecular-metabolism
Conferences & Events
December
9 − 11
2018
Cell Symposia: Metabolites as Signaling Molecules
Seattle, USA
January
13 − 17
2019
Mitochondrial Biology in Heart and Skeletal Muscle
Keystone, USA
February
10 − 14
2019
Obesity and Adipose Tissue Biology
Banff, Canada
February
10 − 14
2019
Functional Neurocircuitry of Feeding and Feeding Disorders
Banff, Canada
February
24 − 28
2019
Tumor Metabolism
Keystone, USA
March
3 − 7
2019
Diabetes: Innovations, Out­comes, Personalized Therapies
Whistler, Canada
March
10 − 14
2019
Microbiome: Mechanisms and Consequences
Montreal, Canada
March
15 − 19
2019
Cancer Metastasis
Florence, Italy
Media Coverage
Supported by