Cover Story

Nicotinamide adenine dinucleotide (NAD+) is an essential co-substrate for several enzyme classes, such as sirtuins and poly ADP-ribose polymerases (PARPs), that regulate a myriad of signaling pathways governing metabolism, healthy aging, and lifespan extension. The NAD+ salvage pathway is the dominant pathway for NAD+ biosynthesis in mammals. In this pathway, nicotinamide phosphoribosyl transferase (NAMPT) plays a central role. NAMPT protein content in skeletal muscle is higher in athletes compared to sedentary individuals, and positively correlated with mitochondrial function, insulin sensitivity, and oxidative capacity in humans. To further probe the putative salutary effects of increased NAMPT activity, Costford, Brouwers et al. generated a mouse transgenic line that overexpressed NAMPT in skeletal muscle (NamptTg). They reveal a fascinating interaction between elevated NAMPT activity in skeletal muscle and voluntary exercise that manifests as a striking improvement of exercise endurance. Voluntary exercise training elicited a 3-fold higher exercise endurance in NamptTg versus WT mice. The precise molecular mechanism for this effect, however, is still to be identified.

Full Text
The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Michael Tarpey
Virginia Tech, Blacksburg, VA, USA
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.molmetab.com/user/alerts
Conferences & Events
January
21 − 25
2018
Organ Crosstalk in Obesity and NAFLD
Keystone, USA
January
21 − 25
2018
Bioenergetics and Metabolic Disease
Keystone, USA
February
4 − 8
2018
Frontiers in Islet Biology and Diabetes
Keystone, USA
Feb. 25 −
March 1
2018
Reducing Diabetes-Related End-Organ Injury
Santa Fe, USA
Feb. 25 −
March 1
2018
Aging, Inflammation and Immunity
Austin, USA
March
4 − 8
2018
Manipulation of the Gut Microbiota for Met. Health
Banff, Canada
March
4 − 8
2018
Microbiome, Host Resistance and Disease
Banff, Canada
June
24 − 26
2018
Cell: Translational Immunometabolism
Basel, Switzerland
Media Coverage
Supported by