Featured Articles

Volume 2 | No. 2 | May 2013

miRNA-mediated gene regulation in POMC neurons is critical to energy homeostasisSchneeberger and colleagues demonstrate that hypothalamic expression of the miRNA processing enzyme Dicer is regulated by nutrient availability. Furthermore, they show that ablation of Dicer-dependent miRNAs in POMC neurons leads to pituitary dysfunction and neurodegenerative obesity.

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Ligand binding to the GLP-1 receptor is largely driven by hydrophobic interactionsThe incretin effect involves binding of the hormone GLP-1 to the extracellular domain (ECD) of the G protein-coupled receptor GLP-1R. Based on homogenous time-resolved fluorescence assays with receptor mutants Patterson and colleagues conclude that hydrophobic interactions with the ECD align the peptide’s N-terminus within the juxtamembrane region of the receptor for activation.

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Neuronal ROS signaling links dietary restriction to lifespan extensionIn nematodes and other organisms dietary restriction is linked to lifetime extension due to increased mitochondrial respiration and formation of reactive oxygen species (mtROS). Schmeisser and colleagues show that mtROS signaling induced by the inhibition of mitochondrial complex I is sufficient to extend the worms’ lifespan even in the absence of dietary restriction.

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High fat diet causes rebound weight gainHigh fat diet causes rebound weight gain Why does successful short-term weight loss improve obesity in some individuals but not in others? The results of McNay and colleagues provide a mechanistic framework for understanding how environmental factors such as macronutrient composition of diet are integrated into the homoeostatic hypothalamus leading to long-term changes in the body weight (BW) set-point.

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Glutamate release mediates leptin action on energy expenditureLeptin plays an important role in the regulation of energy expenditure but the underlying mechanism is not clear. Xu and colleagues demonstrate that glutamate release from leptin receptor-expressing neurons is critical to energy expenditure regulation. Mice with a deletion of the vesicular glutamate transporter 2 exhibit bouts of rapidly reduced energy expenditure, body temperature and locomotion.

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Feeding elicits glutamate release in the mediobasal hypothalamusThe mediobasal hypothalamus (MBH) is a key site for the control of energy balance and glucose homeostasis. Guyenet and colleagues report the first evidence that feeding is associated with rapid release of glutamate in the MBH, and that this response is exaggerated with obesogenic food.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Marc Reitman
National Institutes of Health (NIH), Bethesda, USA
Referring article

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