Featured Articles

Volume 26 | August 2019

Transcriptomic analysis of the ARC after chronic glucocorticoid treatmentGlucocorticoids (GCs) are extensively prescribed medicines due to their potent immunosuppressive and anti-inflammatory properties. Prolonged high-dose GC use is associated with a range of metabolic side effects, including hyperphagia, obesity, and abnormal glucose homeostasis. A potential region involved in driving these GC-induced side effects is the hypothalamic arcuate nucleus. Wray et al. used a global transcriptomic approach to investigate the effects of GCs in the hypothalamus. This revealed a variety of genes involved in energy regulation. The range of both known and novel candidate genes indicates that multiple mechanisms may contribute to the metabolic abnormalities observed with GC treatment.

Abstract | PDF



Reelin is modulated by DIO and has direct actions on POMC neuronsReelin is a large extracellular glycoprotein that is implicated in synaptic formation, remodeling, neuronal migration, and development. There are two known receptors for Reelin, the very low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor 2 (ApoER2). Roberts et al. determined the impact of diet-induced obesity on Reelin, ApoER2, and VLDLR expression in the hypothalamus. They demonstrate a possible mechanism by which Reelin could influence energy homeostasis. In addition, consumption of a high fat diet blunts VLDLR and ApoER2 expression in the hypothalamus and disrupts at least one mechanism by which Reelin acts on arcuate proopiomelanocortin neurons.

Abstract | PDF



Functional alterations of the liver in insulin-deficient diabetes The liver is the central glucoregulatory organ and is exposed to two- to four-fold higher levels of insulin than peripheral insulin target tissues. To determine consequences of missing insulin action in the liver, Backman, Flenkenthaler, et al. used tissue from transgenic pigs expressing mutant insulin for multi-omics analyses. These revealed increased activities in amino acid metabolism, oxidation of fatty acids, ketogenesis, and gluconeogenesis. Their study provides the first multi-omics analyses of liver in insulin-deficient diabetes mellitus and identified key drivers of known functional consequences of insulin deficiency. In addition, previously unknown consequences especially for inflammatory and immune functions of the liver were revealed.

Abstract | PDF



Metabolic stress activates an ERK/hnRNPK/ DDX3X pathway in pancreatic β cells Type 2 diabetes develops because of the dysfunction and eventual loss of pancreatic β cells. An important class of factors that regulate gene expression programs is RNA binding proteins (RBPs), which may be involved in splicing, translation, and RNA stability. Good and colleagues studied the RBP hnRNPK. By focusing on the post-transcriptional regulation of the mRNA encoding JUND, a transcription factor with links to β cell redox homeostasis and apoptosis, they have elucidated a novel ERK/hnRNPK/DDX3X axis that is activated in islets during metabolic stress.

Abstract | PDF



The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Anne White, Jonathan Wray, Erika Harno
University of Manchester, UK
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.sciencedirect.com/journal/molecular-metabolism
Conferences & Events
August
25 − 30
2019
Epigenomics, Nuclear Receptors and Disease
Spetses Island, Greece
September
9 − 12
2019
Ageing and Regeneration
Innsbruck, Austria
September
23 − 25
2019
7th Helmholtz Diabetes Conference
Munich, Germany
October
15 − 18
2019
Nature Conference: Advances in Metabolic Communication
Rio de Janeiro, Brasil
October
15 − 18
2019
13th European Nutrition Conference
Dublin, Ireland
October
27 − 31
2019
Metabolism in Action
Hillerod, Denmark
December
6 − 8
2019
Cachexia, Sarcopenia and Muscle Wasting
Berlin, Germany
Media Coverage
Supported by