Featured Articles

Volume 3 | No. 5 | August 2014

GLP-1R is essential for the control of heart rateIn this study, Ussher and colleagues show that the cardiomyocyte GLP-1R is not essential for the endogenous physiological response to ischemic or cardiomyopathic injury, for GLP-1R-dependent cardioprotection or for the pharmacological GLP-1R-dependent increase in HR. In contrast, basal signaling through the atrial cardiomyocyte GLP-1R is essential for control of HR in mice.

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PTBP1 is required for translation of insulin granule proteinsThe study of Knoch and colleagues demonstrates that beta cells selectively exploit cap-independent translation to rapidly upregulate the biosynthesis of insulin and other insulin granule cargoes and illustrates how this process may be influenced by diabetogenic viruses.

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Hepatic glucose metabolism regulates peripheral energy metabolismThe data of Abdul-Wahed and colleagues emphasize that hepatic glucose production (HGP) should no longer be equaled to endogenous glucose production (EGP). They report report that the specific suppression of EGP from the hepatic site protects not only against T2D, but also against obesity, via hepatic hormonal crosstalk with peripheral tissues

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ER calcium release promotes mitochondrial dysfunctionThe study of Egnatchik and colleagues provide a novel mechanism connecting palmitate-induced depletion of ER calcium stores with dysregulated mitochondrial metabolism, indicating an important role for impaired sarcoendoplasmic reticulum calcium ATPase function and calcium signaling in the initiation of lipotoxic oxidative stress.

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11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasisUsing transgenic mice, Penno and colleagues demonstrate that 11β-HSD1-deficiency results in elevated concentrations of unconjugated BAs in the circulation. The effects are caused, at least in part, by a decreased hepatic expression of Fatp5, likely by a glucocorticoid-independent mechanism. The elucidation of novel 11β-HSD1 functions is important with respect to the development of 11β-HSD1 inhibitors for clinical applications.

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Methyl-donor supplementation prevents the progression of NAFLDThe results of Dahlhoff and colleagues suggest that a methyl-donor supplementation can prevent the progression of lipid accumulation in liver tissues of animals with NAFLD but it cannot reverse NAFLD. This effect is associated with decreased acyl-carnitine levels and hepatic β-hdroxyacyl-CoA dehydrogenase enzyme activity and increased AMPK phosphorylation and enhanced fatty acid oxidation.

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NPY controls stress- and diet-induced fat gainZhang and colleagues utilize a novel mouse model with NPY specifically expressed only in the adrenergic and noradrenergic cells of the catecholaminergic system to show that catecholaminergic NPY activity has significant impact on body weight and adiposity under both an obesogenic diet and stressful conditions.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Andrea Rozo, Doris Stoffers
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
Referring article

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