Featured Articles

Volume 3 | No. 8 | November 2014

The Polycomb protein, Bmi1, regulates insulin sensitivityCannon and colleagues identify a novel role for the Polycomb protein, Bmi1, in the development of insulin resistance. Reduced Bmi1 levels result in alterations in insulin signaling in liver and muscle tissue, which appear to contribute to a striking improvement in whole-body insulin sensitivity.

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CREB has an important role in the β-cell response to GLP-1 receptor signaling Shin and colleagues dispel current opinions about the importance of the bZIP transcription factor CREB in regulating β-cell function and mass. They show that CREB is required in β-cells for the incretin GLP-1 to exert its full effect in potentiating insulin secretion and to assert its protective effects against cytokine-induced cell death.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.

Randy J. Seeley, Henriette Frikke-Schmidt
Department of Surgery, University of Michigan, Ann Arbor, USA
Referring article

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