Featured Articles

Volume 3 | No. 9 | December 2014

GLP-1 regulates lipid metabolism via a gut-brain-liver axisTaher and colleagues show the effects of GLP-1R agonism in insulin resistance. They demonstrate that both short term peripheral and central GLP-1R stimulation induce weight loss, enhanced satiety and prevent fructose-induced dyslipidemia. The mechanism involves altered energy utilization, decreased hepatic lipid synthesis and parasympathetic signaling.

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Arachidonic acid regulates the conversion of white to brite adipocytePisani and colleagues describe a new mechanism by which dietary excess of ω6 polyunsaturated fatty acids may favor obesity. ω6 arachidonic acid strongly inhibits the conversion of white to brite adipocyte involving a prostaglandin/calcium pathway that triggers a decrease in UCP1 expression.

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Impaired insulin secretion in C57BI/6J compared to C57BI/6N miceFergusson and colleagues demonstrate using complementary tests and the hyperglycemic clamp that BI/6J mice have impaired glucose-stimulated insulin secretion compared to BI/6N. Important implications of this finding are discussed.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.

Marc Reitman
National Institutes of Health (NIH), Bethesda, USA
Referring article

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