Featured Articles

Volume 4 | No. 6 | June 2015

Integration of body temperature into the analysis of energy expenditureAbreu-Vieira and colleagues examine the effect of environmental temperature on energy homeostasis and body temperature (Tb) in mice. By integrating Tb data, they provide new insights into the costs of circadian Tb variation, physical activity, and adaptation to the cold.

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Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleusBrain-derived Neurotrophic factor (BDNF) is necessary for preventing hyperphagia and obesity in mice. Liao and colleagues examine the possibility that BDNF affects appetite in part by regulating development of axonal projections and neural inputs of neurons in the arcuate nucleus (ARH). They show that axonal projections of discrete groups of ARH neurons to the paraventricular hypothalamus (PVH) are impaired in mice deficient in long 3’ UTR Bdnf mRNA.

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Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolismJeong and colleagues provide cellular evidence for a hypothalamic neural circuit that negatively regulates brown adipose tissue thermogenesis. They show that cholinergic neurons in the dorsomedial hypothalamus (DMH) directly innervate sympathetic premotor neurons in the raphe pallidus (Rpa) and that elevated cholinergic input to serotonergic neurons in the Rpa reduces brown adipose tissue temperature through activation of M2 muscarinic acetylcholine receptors.

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Causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathyLipid peroxides and their reactive aldehyde derivatives have been postulated to play a causal role in obesity-related cardio-metabolic diseases, and there is a link between polymorphisms/mutations in the glutathione peroxidase 4 encoding gene (gpx4) and human diseases, including obesity. Katunga and colleagues now demonstrate that GPx4 deficiency with diet-induced obesity leads to significant increases in lipid peroxide-derived aldehydes, corresponding to more severe cardio-metabolic derangements including glucose intolerance, dyslipidemia, liver steatosis, and cardiac hypertrophy and fibrosis.

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The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.

Andrea Rozo, Doris Stoffers
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
Referring article

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Lifetime Influence of Genes and Environment
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