Featured Articles

Volume 4 | No. 7 | July 2015

A major role of insulin in promoting obesity-associated adipose tissue inflammationPedersen and colleagues show that the extent of adipose tissue inflammation, including increased macrophage expansion and expression of cytokines, is significantly promoted by high circulating insulin in both lean and obese mice. Their results indicate that reducing circulating insulin levels in obese mice protects against adipose tissue dysfunction and improves systemic insulin sensitivity.

Abstract | PDF



Fibroblast growth factor 21 in metabolically unhealthy obesityBerti and colleagues show that circulating FGF21 levels are more than two-fold higher in metabolically unhealthy obesity (MUHO) subjects as compared to body fat-matched metabolically healthy obesity subjects. Their findings point to FGF21 as cross-talker between the MUHO fatty liver, where it originates, and adipose tissue, where it potently suppresses adiponectin release.

Abstract | PDF



PPAR-α plays a crucial role in behavioral repetition and cognitive flexibility in miceNuclear peroxisome proliferator activated receptor-α (PPAR-α) is best characterized for its contribution to the regulation of lipid homeostasis and its utility as a target for the treatment of dyslipidemia. D’Agostino and colleagues now reveal an unexpected role for brain Ppar-α in the regulation of cognitive behavior in mice. Genetic inactivation resembles a behavioral and cognitive phenotype consistent with preclinical models of schizophrenia and autism spectrum disorder.

Abstract | PDF



UCP1 disruption renders brown adipose tissue a significant source of FGF21 secretionUncoupling protein 1 (UCP1) knockout mice lack the ability to recruit adrenergic thermogenesis in brown adipose tissue (BAT). Keipert and colleagues discover that in UCP1 knockout mice circulating FGF21 levels are highly elevated in response to cold exposure and specifically released from non-functional BAT.

Abstract | PDF



Notch intracellular domain overexpression in adipocytes confers lipodystrophy in miceChartoumpekis and colleagues report a new lipodystrophy model by genetically enhancing the Notch signaling pathway in adipocytes. The model shares common features, such as insulin resistance, diabetes, fatty liver, dyslipidemia and low leptin levels, with previously described mouse lipodystrophy models.

Abstract | PDF



The 60 Second Metabolist
In this section authors briefly report on their work recently published in Molecular Metabolism.

Watch the most recent interview by clicking the video still. The link "referring article" directs you to this author's publication.



Ursula Neumann
University of British Columbia, Vancouver, Canada
Referring article

Other Scientists...
Issue Alert
If you want to be alerted via email when new content that matches your interests is available, please login or register at www.molmetab.com/user/alerts
Conferences & Events
Media Coverage
Supported by