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Past Issue

Volume 6 | No. 6 | June 2017


Original Research Article
Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretionFatou K. Ndiaye, Ana Ortalli, Mickaël Canouil, Marlène Huyvaert, Clara Salazar-Cardozo, Cécile Lecoeur, Marie Verbanck, Valérie Pawlowski, Raphaël Boutry, Emmanuelle Durand, Iandry Rabearivelo, Olivier Sand, Lorella Marselli, Julie Kerr-Conte, Vikash Chandra, Raphaël Scharfmann, Odile Poulain-Godefroy, Piero Marchetti, François Pattou, Amar Abderrahmani, Philippe Froguel, Amélie Bonnefond

Abstract | PDF



Original Research Article
FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasisEmilio P. Mottillo, Eric M. Desjardins, Andreas M. Fritzen, Vito Z. Zou, Justin D. Crane, Julian M. Yabut, Bente Kiens, Derek M. Erion, Adhiraj Lanba, James G. Granneman, Saswata Talukdar, Gregory R. Steinberg

Abstract | PDF



Original Research Article
Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylationJuliane Weiner, Kerstin Rohde, Kerstin Krause, Konstanze Zieger, Nora Klöting, Susan Kralisch, Peter Kovacs, Michael Stumvoll, Matthias Blüher, Yvonne Böttcher, John T. Heiker

Abstract | PDF



Original Research Article
Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disordersXiaoqiang Zhu, Simin Xie, Tian Xu, Xiaohui Wu, Min Han

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Original Research Article
Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathwayBernardo Yusta, Dianne Matthews, Grace B. Flock, John R. Ussher, Brigitte Lavoie, Gary M. Mawe, Daniel J. Drucker

Abstract | PDF



Original Research Article
Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant miceJudit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H. Tsang, Johanna L. Barclay, Henrik Oster

Abstract | Graphical abstract | PDF



Original Research Article
Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cellsAimée Bastidas-Ponce, Sara S. Roscioni, Ingo Burtscher, Erik Bader, Michael Sterr, Mostafa Bakhti, Heiko Lickert

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Original Research Article
NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cellsLaila R.B. Santos, Carole Muller, Arnaldo H. de Souza, Hilton K. Takahashi, Peter Spégel, Ian R. Sweet, Heeyoung Chae, Hindrik Mulder, Jean-Christophe Jonas

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Original Research Article
Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferationBethany A. Carboneau, Jack A. Allan, Shannon E. Townsend, Michelle E. Kimple, Richard M. Breyer, Maureen Gannon

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Original Research Article
Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors developmentLynda Elghazi, Manuel Blandino-Rosano, Emilyn Alejandro, Corentin Cras-Méneur, Ernesto Bernal-Mizrachi

Abstract | Graphical abstract | PDF



Brief Communication
Insulin controls food intake and energy balance via NPY neuronsKim Loh, Lei Zhang, Amanda Brandon, Qiaoping Wang, Denovan Begg, Yue Qi, Melissa Fu, Rishikesh Kulkarni, Jonathan Teo, Paul Baldock, Jens C. Brüning, Gregory Cooney, Greg Neely, Herbert Herzog

Abstract | Graphical abstract | PDF



Brief Communication
Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemiaAnna M. D'souza, Timothy J. Kieffer

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Brief Communication
Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese miceThorsten Michael Becker, Morgana Favero, Vincenzo Di Marzo, Luigia Cristino, Giuseppe Busetto

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Brief Communication
FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissueKathleen R. Markan, Meghan C. Naber, Sarah M. Small, Lila Peltekian, Rachel L. Kessler, Matthew J. Potthoff

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Brief Communication
β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathwayJessica M. Olsen, Robert I. Csikasz, Nodi Dehvari, Li Lu, Anna Sandström, Anette I. Öberg, Jan Nedergaard, Sharon Stone-Elander, Tore Bengtsson

Abstract | Graphical abstract | PDF



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Chun-Xia Yi
Academic Medical Center, University of Amsterdam, The Netherlands
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Lifetime Influence of Genes and Environment
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