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Volume 6 | No. 10 | October 2017


Commentary
The brain strikes back: Hypothalamic targets for peripheral CB1 receptor inverse agonismDaniela Cota

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Commentary
Anti-hypertensive treatment in pregnancy impacts offspring growth and metabolism: Q&ARaffaele Teperino

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Review
Nav1.8 neurons are involved in limiting acute phase responses to dietary fatSwalpa Udit, Michael Burton, Joseph M. Rutkowski, Syann Lee, Angie L. Bookout, Philipp E. Scherer, Joel K. Elmquist, Laurent Gautron

Abstract | Graphical abstract | PDF



Original Research Article
Lorcaserin improves glycemic control via a melanocortin neurocircuitLuke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler

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Original Research Article
Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-lossNatalie Jane Michael, Stephanie Elise Simonds, Marco van den Top, Michael Alexander Cowley, David Spanswick

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Original Research Article
Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signalingJoseph Tam, Gergő Szanda, Adi Drori, Ziyi Liu, Resat Cinar, Yoshihiro Kashiwaya, Marc L. Reitman, George Kunos

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Original Research Article
Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancyRebecca Oelkrug, Beate Herrmann, Cathleen Geissler, Lisbeth Harder, Christiane Koch, Hendrik Lehnert, Henrik Oster, Henriette Kirchner, Jens Mittag

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Original Research Article
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipaseXun Chi, Emily C. Britt, Hannah W. Shows, Alexander J. Hjelmaas, Shwetha K. Shetty, Emily M. Cushing, Wendy Li, Alex Dou, Ren Zhang, Brandon S.J. Davies

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Original Research Article
Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feedingYachen Shen, Hyun Cheol Roh, Manju Kumari, Evan D. Rosen

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Original Research Article
Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetesUrsula H. Neumann, Jessica S.S. Ho, Sam Chen, Yuen Yi C. Tam, Pieter R. Cullis, Timothy J. Kieffer

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Original Research Article
Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartmentShravan Babu Girada, Ramya S. Kuna, Shilpak Bele, Zhimeng Zhu, N.R. Chakravarthi, Richard D. DiMarchi, Prasenjit Mitra

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Original Research Article
Macrophage alternative activation confers protection against lipotoxicity-induced cell deathLingling Dai, Prerna Bhargava, Kristopher J. Stanya, Ryan K. Alexander, Yae-Huei Liou, David Jacobi, Nelson H. Knudsen, Alexander Hyde, Matthew R. Gangl, Sihao Liu, Chih-Hao Lee

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Original Research Article
Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivoLi Li, Baoguo Li, Min Li, Chaoqun Niu, Guanlin Wang, Ting Li, Elżbieta Król, Wanzhu Jin, John R. Speakman

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Original Research Article
Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissueColin J. Palmer, Raphael J. Bruckner, Joao A. Paulo, Lawrence Kazak, Jonathan Z. Long, Amir I. Mina, Zhaoming Deng, Katherine B. LeClair, Jessica A. Hall, Shangyu Hong, Peter-James H. Zushin, Kyle L. Smith, Steven P. Gygi, Susan Hagen, David E. Cohen, Alexander S. Banks

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Original Research Article
Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factorsMichaela Keuper, Stephan Sachs, Ellen Walheim, Lucia Berti, Bernhard Raedle, Daniel Tews, Pamela Fischer-Posovszky, Martin Wabitsch, Martin Hrabě de Angelis, Gabi Kastenmüller, Matthias H. Tschöp, Martin Jastroch, Harald Staiger, Susanna M. Hofmann

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Original Research Article
Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitorNicolai M. Doliba, Qin Liu, Changhong Li, Pan Chen, Chengyang Liu, Ali Naji, Franz M. Matschinsky

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Original Research Article
Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver diseaseChristian Baumeier, Luisa Schlüter, Sophie Saussenthaler, Thomas Laeger, Maria Rödiger, Stella Amelie Alaze, Louise Fritsche, Hans-Ulrich Häring, Norbert Stefan, Andreas Fritsche, Robert Wolfgang Schwenk, Annette Schürmann

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Original Research Article
Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weightDeepti Ramachandran, Rosmarie Clara, Shahana Fedele, Junmin Hu, Endre Lackzo, Jing-Yi Huang, Eric Verdin, Wolfgang Langhans, Abdelhak Mansouri

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Original Research Article
Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout miceKavaljit H. Chhabra, Donald A. Morgan, Benjamin P. Tooke, Jessica M. Adams, Kamal Rahmouni, Malcolm J. Low

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Original Research Article
Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMPBodil Ingerslev, Jakob S. Hansen, Christoph Hoffmann, Jens O. Clemmesen, Niels H. Secher, Mika Scheler, Martin Hrabĕ de Angelis, Hans U. Häring, Bente K. Pedersen, Cora Weigert, Peter Plomgaard

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Brief Communication
Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestineLeslie L. Glass, Fernando J. Calero-Nieto, Wajid Jawaid, Pierre Larraufie, Richard G. Kay, Berthold Göttgens, Frank Reimann, Fiona M. Gribble

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Brief Communication
Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intoleranceSibylle Sabrautzki, Gabriele Kaiser, Gerhard K.H. Przemeck, Felicia Gerst, Estela Lorza-Gil, Madhura Panse, Tina Sartorius, Miriam Hoene, Susan Marschall, Hans-Ulrich Häring, Martin Hrabě de Angelis, Susanne Ullrich

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Brief Communication
Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNAMorten Lundh, Kaja Pluciñska, Marie S. Isidor, Patricia S.S. Petersen, Brice Emanuelli

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Brief Communication
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiencyTinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg

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Brief Communication
Neonatal pancreatic pericytes support β-cell proliferationAlona Epshtein, Eleonor Rachi, Lina Sakhneny, Shani Mizrachi, Daria Baer, Limor Landsman

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Ursula Neumann
University of British Columbia, Vancouver, Canada
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